Once a sweet old lady, Madam Foster, opened an unusual shelter where the residents are not children or animals, but imaginary friends! The shelter is run by a strict rabbit, Mr. Harriman, and assisted by Madam Foster's granddaughter Frankie Foster. There are the most unusual and diverse friends, from the smallest to the largest, from the cutest to the terribly scary. But the most mischievous of them all is Bloo. The restless Beauregard constantly causes trouble for his friends—Wilt the One-Armed Basketball Player, the timid Eduardo, Coco, the Bird-Plane-Palm, and his creator Meg.