A world in which demons feed on humans, and those very people do not even suspect it. Long ago, the most powerful demon was defeated, and parts of its body were scattered across the world. Whoever can collect them and devour them will gain unlimited power and even be able to destroy humanity. A physically fit high school student, Yuji Itadori, is troubled by pressing problems—he spends almost all his time in the hospital with his grandfather, so, to get away from persistent offers to join sports clubs, he enrolls in the occult club. And suddenly he finds himself at the epicenter of a battle for humanity's fate, when his adversaries remove the enchantment from a certain magical artifact.